Frequently Asked Questions on Software Development Services

Today when digitization is something that enterprises across the globe are taking very seriously, what they need today is to make a mark of their own in order to stand out from the competition in this highly competitive world. Digitization is something that requires automation of different processes in order to increase efficiency and productivity and also bring higher ROI to the organisation.

In order to make digitisation a reality, enterprises today need to invest in software that helps in the automation of the different processes efficiently and increase the productivity of the teams working in the different departments. While buying software off the shelf is an option, the best bet is to invest in custom software. This is because custom software is software that is tailor made for the specific needs of the organisation.

Leading IT Solutions providers like The Digital Group,Oxagile and Hexaware provide custom software development services for every need and requirement of businesses today. Before a business owner decides to make the investment, here are some frequently asked questions.

1] What can custom software development service providers help a business with?

Well, it includes everything from the initial cost analysis to creating product road maps and establishing roles to be played by different teams. These firms are committed to understanding the exact requirements of every business, including the goals and targets, before they suggest an approach that is sure to bring results.

2] How does one co-ordinate with the custom software development servicesprovider?

Most leading firms have their website in which they have their contact numbers enlisted. Once a business reaches out to them, their team will co-ordinate for the project brief and the process to proceed further. They are more than happy to discuss the whole thing out and come up with ideas.

3] Should one do any kind of homework before getting in touch with a custom software development services provider?

Before one gets in touch, it is very important to have a clear understanding of what exactly one wants. It’s all about having a clear vision in mind that one can share with the development team. The clearer the vision is, the easier it will be to convey what actually one wants, without spending months on iterations.

4] How much knowledge of programming should one have in order to get a custom software developed for their business?

The point here is it is the responsibility of the custom software development services team to take care of all the programming.Hence, the business owner is not expected to be thorough with coding or things like that.

5] How much time does it take to build a custom software?

There is no fixed time as such when it comes to developing a custom software. It all depends on various factors like the complexity of the project, budget involved, scope of the project, to name a few. Most leading providers provide business owners a window of 2 weeks or so in order to decide if the pace of work is what meets the criteria. If not, there is always an option to retract with no penalties whatsoever.

So that was about some of the frequently asked questions on custom software development services. Every business today should realise its importance and invest in one in order to stay ahead of the competition and meet the business goals.

Nature: Eight Proteins Transform Mouse Stem Cells into Oocyte-like Cells

A combination of eight proteins can transform mouse stem cells into cells that look much like immature eggs, oocytes. The resulting ovomatrix-like cells cannot undergo meiosis, but can be fertilized by sperm and then divide until they reach the eight-cell stage of embryonic development, the researchers reported.

“This suggests that there can be a direct transition from stem cells to oocytes. I think this is exciting,” says Petra Hajkova, a developmental epigeneticist at Imperial College London, which will help researchers explore the basic biology of oocyte development.

In the future, the study could help clone endangered animals or help women with mitochondrial diseases have healthy children, said Yoshihiko Yamasaki (from Kyushu University), one of the authors of the article.

Oocytes are a relatively scarce cell type in the human body and are not well understood, which has attracted him and colleagues to explore how they develop, Yamasaki said. Past studies have demonstrated that changes in gene expression are essential for very early primordial germ cell migration into oocytes. On this basis, Hamazaki and colleagues performed more gene expression analysis and identified 27 candidate transcription factors that function during migratory transformation. To test the function of each transcription factor, the team used pluripotent embryonic stem cells (ESC) that knock out or inactivate the genes encoding transcription factors one by one. “It is much easier to construct knockout pluripotent embryonic stem cells than to construct knockout mice, but despite this, considerable work needs to be done to prepare 27 knockout pluripotent embryonic stem cells,” Yamasaki said.

The experimental results revealed eight transcription factors essential for oocyte development: NOBOX, FIGLA, TBPL2, SOHLH1, STAT3, DYNLL1, SUB1 and LHX8. The team then cultured another group of embryonic stem cells and “overexpressed” the genes that produce these eight transcription factors, which as a result forced these embryonic stem cells into an oocyte-like state.

He explained: “It is thought that oocytes develop from germ cells, but we can successfully prepare oocytes from non-germ cells.” “At first, I was so surprised that I could not believe my results, so I repeated the experiment again and again, and when I got the same results, I was finally sure.”

In subsequent experiments, ovoid cells did not continue to divide into daughter cells with half of the chromosomes—meiosis is an important part of reproduction. But the researchers said that when the team introduced wild-type mouse sperm into the culture, the oocytes did divide into cell clusters of 8 cells and then could not survive, possibly because these cells had too many chromosomes.

Richard Schultz, a cell biologist at the University of California, Davis, commented that the work was impressive in identifying core transcription factors that can push embryonic stem cells to look like oocyte states. But ovoid cells do not undergo meiosis, so they are not functional. This was a great improvement, but only 95 percent was completed. We haven’t got 100 percent information yet “— to understand which essential key factors can promote germline oocytes to develop and mature into oocytes, which then mature into eggs with half of their chromosomes.

Although no pathway was found to direct meiosis, this work “allowed us to produce large numbers of oocytes. We believe that this technology can accelerate basic biological research in oocytes, which remain one of the most mysterious cell types.” Yamasaki explained that due to the large number of oocytes produced by the team’s technology, this work may help improve animal cloning. The cytoplasm of the induced oocyte-like cells did not show any abnormalities and therefore may also be valuable for reproductive problems in women with mitochondrial diseases. Children inherit the disease from their mothers, but the use of enucleated stem cells to induce oocytes (which may have healthy mitochondria) as carriers of the nuclei of oocytes from affected mothers may be a solution to this problem.

Manhood Health and Anejaculation: What to Do If It Occurs

Men who are interested in maintaining an active and enjoyable romantic life make manhood health a top priority. After all, good manhood health has a direct impact on how much please a man gets from his sensual activities. But there are some conditions, such as Anejaculation, which can have a serious effect on a man’s romantic life even if the manhood itself remains in good shape.

What is Anejaculation?
Most men have never heard of Anejaculation, which is a in some ways a good thing. It’s a fairly rare condition, which means that the majority of men won’t have to deal with it. But what is it, exactly?

The word “Anejaculation” means “no release,” and that describes the problem quite accurately: men with this condition are unable to produce seed. The man still makes it, mind you, but the prostate gland and the seminal ducts can’t release the seed, often due to blockage.

This doesn’t mean that they don’t get hard or react to stimulation. It also doesn’t necessarily mean that they can’t get off; many men with Anejaculation do indeed reach the height of pleasure, but they do so without releasing any fluid.

Forms of Anejaculation
There are several kinds of Anejaculation. Situational Anejaculation means that there are some times when a man can release and others when he cannot. Situational Anejaculation is often the result of tension and anxiety. For example, a man may be asked to give a fluid sample at a doctor’s office but may feel pressured and may fail to release seed despite going through all the proper motions. In some other instances, a man may come during solo play but not with a partner (or the other way around, as well).

Causes
There can be several causes of Anejaculation. Situational Anejaculation is most often related to psychological factors, especially stress. Diabetes, Parkinson’s disease and other conditions (including spinal cord issues) that affect the nervous system can also be the culprit, as can traumatic injury or surgery to the lap and surrounding areas. Low androgen levels and certain psychotropic medications may also be part of the problem.

Treatment
Treatment depends upon the root cause. Psychological factors can be worked through with a trained mental health therapist. Switching medications or hormone therapy may be appropriate in other cases, as can properly managing underlying conditions, such as diabetes, that create the Anejaculation situation. Vibrator therapy can be useful in producing early release in some cases, as can electrical stimulation; both should be overseen by a doctor for safety reasons.

Manhood health can be impacted by Anejaculation when the manhood continues to receive stimulation after release (or in search of an release), because the man assumes the lack of early release means that the sensual experience is not over. This can lead to extreme soreness which can be alleviated through the application of a top flight manhood health crème (health professionals recommend Man1 Man Oil). Soothing the manhood in such situations requires a crème with shea butter (one of the premier emollients) and vitamin E, both of which provide healing hydration for a manhood that has been rubbed raw. Also essential is the presence of vitamin C in the crème, as vitamin C is known for its role in collagen production, which in turn gives tone and elasticity to manhood skin. Rough stimulation, due to Anejaculation or other reasons, requires proper regular care to keep the manhood healthy.

Visit http://www.menshealthfirst.com for additional information on most common manhood health issues, tips on improving manhood sensitivity and what to do to maintain a healthy manhood. John Dugan is a professional writer who specializes in men’s health issues and is an ongoing contributing writer to numerous websites.